Changing human–wildlife interaction is a growing global concern. The implications are severe and include life threats to both humans and wildlife, loss of income, crop raiding, property damage, loss of peace of mind, and reduced community support in conservation efforts. The experiences and perceptions of different indigenous/tribal communities living in the Wayanad Wildlife Sanctuary towards changing human–wildlife interactions are examined. The findings show that the experiences of human–wildlife interaction and conflict differ from one community to another and vary across the study areas. Community-specific, livelihood-focused, micro-level mitigation measures are suggested to derive sustainable solutions for mitigating human–wildlife conflicts.