Anti-inflammatory effect and mechanism of action of ellagic acid-3,3′,4-trimethoxy-4′-O-α-Lrhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages
| Title | Anti-inflammatory effect and mechanism of action of ellagic acid-3,3′,4-trimethoxy-4′-O-α-Lrhamnopyranoside isolated from Hopea parviflora in lipopolysaccharide-stimulated RAW 264.7 macrophages |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Prabha B., Sini S., Priyadarshini T.S, Sasikumar P., Gopalan G., Joseph J.P, Jithin M.M, Sivan V.V, Jayamurthy P., Radhakrishnan K.V |
| Journal | Taylor & Francis Group |
| Start Page | 1 |
| End page | 6 |
| Date Published | 11/2019 |
| Type of Article | Online Journal |
| ISSN | 1478-6419 |
| Keywords | 3’, 4-trimethoxy-4’-Oa- L-rhamnopyranoside, antiinflammatory effect, Dipterocarpaceae, ellagic acid-3, Hopea parviflora |
| Abstract | Phytochemical investigation of the stem bark of Hopea parviflora resulted in the isolation of 9 compounds; which includes friedelin (1), friedelin-3b-ol (2), (-)-ampelopsin A (3), (-)-E-viniferin (4), (-)-hopeaphenol (5), vaticaphenol A (6), 2,4,8-trihydroxyphenanthrene- 2-O-glucoside (7), ellagic acid-3,3’,4-trimethoxy-4’-O-a-Lrhamnopyranoside (8) and b-sitosterol-b-D-glucoside (9). Among them, compounds 1, 2, 6, 7, 8 and 9 are isolated for the first time from this species. Further, we evaluated the anti-inflammatory activity of compounds 4, 5, 6, 7 and 8. In this study, compound 8 inhibited the activity of proinflammatory mediators like NO, TNF-a, IL-6, 5-LOX and COX-2, also promoted the action of anti-inflammatory mediator like IL-10 via inhibition of the NF-jB pathway in LPS-stimulated RAW 264.7 macrophages. |
| Original Publication | Taylor & Francis Group |
